Abstract: Clinical Curative Effect of Laparoscopic Radical Cystectomy with Orthotopic IlealNeobladder: A Report of 15 casesJiewu SHI, Linyu ZHOU, Qiang XUAN, Yiao TAN, Aijun GU, Jin YUCorrespondence to: Linyu ZHOU, E-mail: zhoulinyua@163.comDepartment of Urology, Anhui Provincial Hospital Affiliated to Anhui Medical College, Hefei 230001, ChinaAbstract Objective: To summarize the experience and benefits of laparoscopic radical cystectomy and orthotopic ileal neoblad-der for bladder cancer. Methods: Fifteen patients (11 males and 4 females) with bladder carcinoma underwent laparoscopic radical totalcystectomy with orthotopic ileal neobladder formation. Their mean age was 61.8 years ( range, 46 to 72 years ). Using 5 trocars, thesurgeon conducted the procedure through 2 ports on the left side, and the assistants participated on the right side while holding the lapa-roscope. The lower segments of the ureters were dissociated and pelvic lymphadenectomy was performed from the right to the left. Rad-ical cystoprostatectomy was performed for the male patients. The whole bladder, uterus and appendage were removed for the femalepatients. A 4 to 5 cm incision ( median value ) in the lower abdomen was made to remove the surgical specimens and construct the ilealpouch. A 50 cm ileal loop was taken from the abdominal cavity, isolated, detubularized and reconfigured into an "M ''shaped pouch withrunning sutures. The anti-refluxing ureter implantation was performed by inserting 1 cm of ureter into the pouch and suturing them to-gether. Results: The mean surgical duration was 6.3 h ( 5-8 h ), and the blood loss was 400～800 mL with a mean of 447 mL. The bow-el recovery time of all patients was 3-4 days. The capacity of the neobladders was about 300 ml. Ureter reflux was not found using IVUor cystography a month after surgery. All patients had restored urination function 4-6 weeks after surgery. Conclusion: Laparoscopicradical cystectomy has the advantage of being minimally invasive with a rapid recovery. Laparoscopic neobladder-ureter anastomosisreduces bleeding, sphincter injury, intestinal adhesion, abdominal cavity pollution and nerve bundle injury. Laparoscopic radical cystec-tomy and neobladder-ureter anastomosis may become an alternative surgical method for patients with localized bladder cancer that hasinvaded muscle.Keywords Laparoscopic technique; Bladder neoplasm; Radical cystectomy; Ileal neobladder